Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

Dr. Xing Liu (left), a postdoctoral fellow in the Lieberman lab, will investigate the  underlying mechanism responsible for global mRNA decay during programmed cell death. Decay of mRNA, but not noncoding RNAs, which is triggered when the mitochondrial outer membrane is disrupted early in cell death, is a previously unrecognized mediator of programmed cell death.

Dr. Wei (right) a postdoctoral fellow in the Alt lab has previously identified classes of recurrent DNA double strand breaks (RDC) that occurred frequently in the body of long genes in murine neural stem and progenitor cells (NSPCs).  These genes have been implicated in neuropsychiatric diseases and many are rearranged in cancers, including brain cancers.   Dr. Wei aims to elucidate the roles of RDCs in NSPCs in neuronal cell diversification and brain diseases development.Dr. Wei a postdoctoral fellow in the Alt lab has previously identified classes of recurrent DNA double strand breaks (RDC).