Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

Minchul Kim will investigate molecular mechanisms of totipotency,  a transient developmental state which possesses the ability to differentiate into both placental and embryonic tissues. Using the phenomenon that cultured embryonic stem cells include a subpopulation of totipotent cells together with CRISPR-Cas9 technology, Minchul plans to perform unbiased screening to identify regulators of totipotency. Identified factors will be studied in detail through epigenomic approaches and in vitro fertilization. Results of this study will have significant impact in both basic developmental biology and regenerative medicine.