Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

 

 

Cardiac hypertrophy is characterized by enlargement of cardiomyocyte and thickening of heart muscle- a condition that can ultimately lead to heart failure. Epigenetic modifications, such as DNA methylation, are hypothesized to play a critical role during the hypetrophic growth of cardiomyocytes. TET family of proteins regulate DNA demethylaiton by converting 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC),  5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). During this 2-year award Dr. Wang aims to determine the roles of TET proteins as well as 5mC derivatives in development of cardiac hypertrophy.