Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

Dr. Wei has received a 2-year postdoctoral fellowship from the National Cancer Center (NCC) for supporting her research in the contribution of the recurrent DNA double strand breaks (DSBs) in medullonlastoma (MB). Human MB is the most common childhood brain cancer and which causes the highest cancer-related mortality in children. MBs exhibit oncogenic recurrent genomic rearrangements that involve joining of DNA DSBs, but the origin of such DSBs is unknown. Dr. Wei aims to identify DNA DSBs that contribute to the generation of various types of recurrent genomic instability found in MBs. This study could facilitate the understanding of how MBs are developed and maintained and ultimately lead to development of therapeutic strategies for their management.