Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

Dr. Beerman, an Instructor in Pediatrics in Dr. Derrick Rossi's laboratory, has received a five-year career development award to establish the potential of aged blood cells to be reprogrammed to cells with hematopoietic stem cell function. 

Aging of the blood system is associated with many detrimental phenotypes having clinical significance including anemia, increased autoimmunity, and elevated rates of malignancy. Increasing evidence implicates age-associated alterations of the hematopoietic stem cell (HSC) compartment as a primary source of hematopoietic dysregulation. Under Dr. Rossi's mentorship, Dr. Beerman has established functional, molecular, and epigenetic changes in the aged HSC compartment that underlie aging phenotypes, in a cell-autonomous manner. These findings suggest that restoring functional potential to the aged HSC compartment will mitigate many negative phenotypes associated with blood aging. 

By examining transcriptional as well as epigenetic landscapes of the reprogrammed, or partially reprogrammed blood cells, Dr. Beerman will establish the potential for functional restoration of an aged blood system through reprogramming.