Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

Dr. Hongxia Fu, a postdoctoral fellow in the Springer lab, is the 2014 recipient of the Judith Graham Pool Postdoctoral Research Fellowship, awarded by the National Hemophilia Foundation.  The title of her proposal is “Mechanoregulation of Von Willebrand Factor Inhibition and Activation”.  Von Willebrand factor (VWF) is a blood protein that plays an important role in platelet adhesion and aggregation during hemostasis. The hemostatic function of the VWF is mediated by the hydrodynamic flow through the blood vessels, resulting in conformational changes of this protein.  However, the mechanisms of VWF inhibition under normal blood circulating conditions and its activation after injury remain elusive.  The current study will combine protein engineering, immunofluorescence, and an in-vivo animal model to elucidate the mechanisms of VWF regulation.  This work could provide the basis for more targeted approaches for the diagnosis and treatment of hemophilia in the future.