Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

Dr. Heng Ru, a postdoctoral fellow in the Wu lab, was recently awarded the Cancer Research Institute Irvington Postdoctoral Fellowship. During the three-year fellowship, Dr. Ru will investigate the catalytic and regulatory mechanism of the recombination-activating gene (RAG) protein complex, which is fundamental to our understanding of V(D)J recombination and generation of antibody diversity. Genetic mutations and dysregulation of RAGs are associated with many human diseases, such as severe combined immunodeficiency, T cell acute lymphoblastic leukemia, chronic myelogenous leukemia, systemic lupus erythematosus, as well as malignancies outside the immune system, including colorectal cancer. The funded project will reveal the molecular basis for the pathological relationships between RAGs and these diseases and provide new insights into their treatment.