Contact: Alexander Shtifman
Phone: 617-713-8989
alex...@childrens.harvard.edu

When the human body is infected with a foreign pathogen, B cells diversify antibody repertoire by introducing mutations into the antibody variable regions, which process is initiated by Activation-Induced cytidine Deaminase (AID). However, if AID targets the wrong genes it can cause the genetic mutations that lead to cancer, particularly B cell lymphomas.  Dr. Meng’s project will investigate the mechanisms that regulate AID activity. These studies should enhance the understanding of how AID collateral damage, such as deleterious off-target mutations, double strand breaks, and chromosomal translocations are minimized.