The wear and tear of life takes a cumulative toll on our bodies. Our organs gradually stiffen through fibrosis, which is a process that deposits tough collagen in our body tissue. Fibrosis happens little by little, each time we experience illness or injury. Eventually, this causes our health to decline.
"As we age, we typically accumulate more fibrosis and our organs become dysfunctional," says Denisa Wagner, PhD, the Edwin Cohn Professor of Pediatrics in the Program in Cellular and Molecular Medicine and a member of the Division of Hematology/Oncology at Boston Children's Hospital and Harvard Medical School.
Ironically, fibrosis can… Read Full Article »
When he was only two days old, Jan Brandt rushed her son Steven from a hospital in New Hampshire to Children's Hospital in Boston. The boy had an alarmingly low level of platelets, the red blood cells that… Read Full Article »
Back in the late 1970s, when I first learned I had a fatal bone marrow disease called aplastic anemia, I had no idea that CBRI would play an essential role in my cure. My bone marrow had stopped… Read Full Article »
In a new issue of Journal of Clinical Investigation, Senior Investigator Denisa Wagner, Ph.D., and colleagues have shed light on the regulatory powers of a molecule called CalDAG-GEFI, which according to Wagner exists as a kind of "red… Read Full Article »
Senior Investigator Judy Lieberman, M.D., Ph.D., will be a featured scientist in a new Harvard publication called Science Connections. She is one of 20 scientists from the Harvard universe, including research institutions and affiliated hospitals, who are profiled… Read Full Article »