The Program in Cellular and Molecular Medicine (PCMM) would like to welcome Dr. Hidde Ploegh who has joined the Department of Medicine at Boston Children's Hospital as of December 2016. Pending completion of his appointment to Harvard Medical School, Dr. Ploegh, who is a former PCMM Scientific Advisory Board member, has been nominated to become a PCMM Investigator and also has been nominated to serve as the first incumbent of a Professorship newly endowed by G.D. Yancopoulos in honor of Frederick W. Alt at Boston Children’s Hospital and Harvard Medical School. Prior to joining PCMM, Dr. Ploegh… Read Full Article »
An AIDS vaccine able to fight any HIV strain has thus far eluded science. HIV frequently mutates its coat protein, dodging vaccine makers’ efforts to elicit sufficiently broadly neutralizing antibodies.
Yet sometimes HIV-infected people can… Read Full Article »
From the tension of contracting muscle fibers to hydrodynamic stresses within flowing blood, molecules within our bodies are subject to a wide variety of mechanical forces that directly influence their form and function. By analyzing the responses of… Read Full Article »
The genome of developing brain cells harbors 27 clusters, or hotspots, where its DNA is much more likely to break in some places than others, according to research from Harvard Medical School and Boston Children’s Hospital.… Read Full Article »
Researchers in the laboratory of Frederick Alt at the Howard Hughes Medical Institute and Program in Cellular and Molecular Medicine (PCMM) at Children's Hospital Boston, led by Leng-Siew Yeap and Joyce K. Hwang, have fundamentally… Read Full Article »
The saying in the design world is that form follows function. But in biology, and protein biology in particular, it would be more correct to say that form begets function. Shape and structure are the foundation… Read Full Article »