Multimedia

Congratulations to Dr. Srigokul Upadhyayula on his promotion to Instructor in Pediatrics at Harvard Medical School.
Live-Cell Visualization of Pre-mRNA Splicing with Single-Molecule Sensitivity Martin et al Cell Reports 2012
Visualization in real-time of splicing and intron turnover in the nucleus of living cells was achieved by combining genomic integration of a single reporter gene in human cells, intron labeling with fluorescent proteins, and spinning-disk confocal microscopy. By determining the lifetime of single introns we showed that different types of introns have distinct splicing kinetics depending on their size, splice-site strength, and relative position in the transcript.
Hi-Fi-Sci - Music & Science Animation
Hey Music & Science lovers, help us bring together the work of composers & scientists in a unique, ambitious multimedia event!
Caught on Film
Latest news article by Jake Miller entitled "Single-molecule movies capture the chaotic origins of dynamic assembly in cells" published August 2, 2012 in the Harvard Medical School website. The Latest news article describes the findings by Ema Cocucci and Francois Aguet which appeared in the August 3, 2012 issue of Cell.
Click HereClick Here
The first moments in the life of a clathrin-coated pit
Clathrin-mediated endocytosis August 2012
This molecular animation made collaboratively by Janet Iwasa and Tom Kirchhausen shows a 3D simulation of how coated vesicles form in real time, including features of numerous experimentally-derived atomic structures, cellular dynamics and molecular interactions.
3D simulation of how endocytic clathrin coated vesicles form, 2012 (Tom Kirchhausen and Janet Iwasa) 3D simulation of how endocytic clathrin coated vesicles form, 2012 (Tom Kirchhausen and Janet Iwasa)
The Animators of Life
The New York Times, November 15, 2010 - By ERIK OLSEN - Technology - 1147 words
The Animators of Life by Erik Olsen, NYT , November 2010 The Animators of Life by Erik Olsen, NYT , November 2010
Nuclear envelope starts with a clean sheet, JCB podcast August 2011
Human Pit
Formation of a clathrin coated pit performed by a group of students attending the Cellular and Molecular Biology of Membranes advance course held between June 8 and June 19, 2009 in Cargese, France.
Clathrin-mediated endocytosis September 2008
This animation shows the process of clathrin-mediated endocytosis of transferrin receptors, focusing on the assembly and disassembly of the clathrin cage
3D simulation of how endocytic clathrin coated vesicles form, 2008 (Tom Kirchhausen and Janet Iwasa) 3D simulation of how endocytic clathrin coated vesicles form, 2008 (Tom Kirchhausen and Janet Iwasa)
The birth of a clathrin coat
3D Simulation of how a Clathrin Coat forms (Tom Kirchhausen and Allison Bruce) 2000 3D Simulation of how a Clathrin Coat forms (Tom Kirchhausen and Allison Bruce) 2000
The birth of a clathrin coat The birth of a clathrin coat
Sec23p/24p Complex of COPII Sec23p/24p Complex of COPII
X-ray structure of the terminal domain of clathrin, Ter Haar, Musacchio, Harrison & Kirchhausen Cell 1998 X-ray structure of the terminal domain of clathrin, Ter Haar, Musacchio, Harrison & Kirchhausen Cell 1998
Live-cell imaging of Clathrin-coated pit and coated vesicles formation
AP-2 labeled with sigma (symbol)2-EGFP w/ Voice Description,Erlich et al Cell 2004 AP-2 labeled with sigma (symbol)2-EGFP w/ Voice Description,Erlich et al Cell 2004
Fluorescent LDL as a probe to identify single-endocytic clathrin-coated pits/vesicles
Clathrin labeled with EGFP-LCa and LDL labeled with DiI w/ Voice Description Clathrin labeled with EGFP-LCa and LDL labeled with DiI w/ Voice Description
Fluorescent reovirus as a probe to identify single-endocytic, Ehrlich et Cell 2004
Endocytosed (a) Endocytosed (a)
Endocytosed (b) Endocytosed (b)
Non-Endocytosed Non-Endocytosed
Dnm1p localization and mitochondria constrictions and fissions, Legesse-Miller et al MBoC 2003
4D Dnm1p and mitochondria constrictions and fission 4D Dnm1p and mitochondria constrictions and fission
3D yeast mitochondria in the absense of Dnm1p 3D yeast mitochondria in the absense of Dnm1p
3D yeast mitochondria in the presence of Dnm1p 3D yeast mitochondria in the presence of Dnm1p
IlLUSTRATIONS
SELECTED MAGAZINE COVERS
NatureNature
CellCell
CMLSCMLS
Current BiologyCurrent Biology
JCBJCB
Current Opinion in ImmunologyCurrent Opinion in Immunology
ImmunityImmunity
Nature Structural & Molecular BiologyNature Structural & Molecular Biology
ScienceScience
TrafficTraffic
Molecular Biology of the CellMolecular Biology of the Cell
Molecular Biology of the CellMolecular Biology of the Cell
NatureNature
Kirchhausen Laboratory Retreat 2014
On the way...whoo hooOn the way...whoo hoo
Which way is it?Which way is it?
I'm not sureI'm not sure
Checking out the poolChecking out the pool
Time for talksTime for talks
Time for laser tag...yay!Time for laser tag...yay!
Winner of the GirlsWinner of the Girls
Winner of the guysWinner of the guys
Tough guysTough guys
Watch out belowWatch out below
Dinner at Masa Japanese RestaurantDinner at Masa Japanese Restaurant
Party back at the hotelParty back at the hotel
Lab Photo Gallery
Goodbye lunch for KatiGoodbye lunch for Kati
Lab Photo Gallery 2012
Steeve's FarewellSteeve's Farewell
TK BDayTK BDay
Areas of Research

Learn more about research at the IDI by exploring our areas of research below: