Investigators

A great variety of path-breaking research is being done in our 15 distinct investigator-led laboratories.

Our labs are led by world-class investigators who are esteemed in their research fields, and whose bold work represents the future of biomedical research.

Click on the separate areas below to learn more about the investigators and the research they pursue with great dedication.

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Chester A. Alper, M.D.
Chester A. Alper, M.D.

The Alper lab studies the genetics of complex (polygenic) disease in humans, with a focus on autoimmunity, particularly within the genes of…

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Frederick Alt, Ph.D.
Frederick Alt, Ph.D.

Frederick Alt received his Ph.D. in Biology from Stanford University in 1977 where he worked with Robert Schimke and discovered gene amplification…

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Michael C. Carroll, Ph.D.
Michael C. Carroll, Ph.D.

The B cell receptor (BCR) is essential for survival of mature B cells and its specificity dictates the cells’ fate from early…

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Anne Goldfeld, M.D.
Anne Goldfeld, M.D.

A major focus of the Goldfeld laboratory is understanding the mechanisms of transcriptional activation of the tumor necrosis factor (TNF) gene. Through…

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Sun Hur, Ph.D.
Sun Hur, Ph.D.

Correct discrimination of "self" vs "non-self" nucleic acids by the innate immune system is essential for host defense against viral infection.  A…

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Tomas Kirchhausen, Ph.D.
Tomas Kirchhausen, Ph.D.

Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular we study the…

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Judy Lieberman, M.D., Ph.D.
Judy Lieberman, M.D., Ph.D.

The Lieberman lab studies cytotoxic T lymphocytes (CTL) that are key cells in the immune defense against viral infection and cancer. 

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Hidde Ploegh, Ph.D.
Hidde Ploegh, Ph.D.

The Ploegh Lab studies the various tactics that viruses employ to evade our immune responses, and the ways in which our immune…

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Eileen Remold, Ph.D.
Eileen Remold, Ph.D.

Neutrophils and Pulmonary Infection
The Remold-O’Donnell Laboratory studies the role of SerpinB1 in protecting the host defenses of the lung against microbial…

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Derrick Rossi, Ph.D.
Derrick Rossi, Ph.D.

The unique ability of stem cells to perpetuate themselves through self-renewal, and to give rise to mature effector cell types in a…

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Timothy Springer, Ph.D.
Timothy Springer, Ph.D.

Research Interest:

We work on receptor-ligand interactions and signal transmission across membranes. Graduate students and postdoctoral fellows find my lab fascinating because…

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Denisa D. Wagner, Ph.D.
Denisa D. Wagner, Ph.D.

 

The Wagner lab studies how blood cells respond to injury or stressful situations and initiate defensive or reparatory processes. Specifically, they…

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Florian Winau, M.D.
Florian Winau, M.D.

The Winau lab studies diverse aspects of antigen presentation, a process pivotal for activation of T-lymphocytes. Winau and colleagues investigate three principal…

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Wesley Wong, Ph.D.
Wesley Wong, Ph.D.

We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role…

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Hao Wu, Ph.D.
Hao Wu, Ph.D.

The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors.…

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Yi Zhang, Ph.D.
Yi Zhang, Ph.D.

Epigenetic modifications, particularly DNA methylation and covalent histone modifications, play an important role in regulating chromatin dynamics and therefore have a significant…

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