Investigators
Areas of Research
Learn more about our research by exploring our areas of research below:
A great variety of path-breaking research is being done in our 18 distinct investigator-led laboratories.
Our labs are led by world-class investigators who are esteemed in their research fields, and whose bold work represents the future of biomedical research.
Click on the separate areas below to learn more about the investigators and the research they pursue with great dedication.
- Chester A. Alper, M.D.
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The Alper lab studies the genetics of complex (polygenic) disease in humans, with a focus on autoimmunity, particularly within the genes of…
- Frederick Alt, Ph.D.
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The broad focus of the Alt lab is the elucidation of mechanisms that maintain genomic stability in mammalian cells. More specifically, the…
- Michael C. Carroll, Ph.D.
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The B cell receptor (BCR) is essential for survival of mature B cells and its specificity dictates the cells’ fate from early…
- Anne Goldfeld, M.D.
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A major focus of the Goldfeld laboratory is understanding the mechanisms of transcriptional activation of the tumor necrosis factor (TNF) gene. Through…
- Sun Hur, Ph.D.
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Correct discrimination of "self" vs "non-self" nucleic acids by the innate immune system is essential for host defense against viral infection. A…
- Tomas Kirchhausen, Ph.D.
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Our research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular we study the…
- Judy Lieberman, M.D., Ph.D.
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The Lieberman lab studies cytotoxic T lymphocytes (CTL) that are key cells in the immune defense against viral infection and cancer.
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- Eileen Remold, Ph.D.
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Neutrophils and Pulmonary Infection
The Remold-O’Donnell Laboratory studies the role of SerpinB1 in protecting the host defenses of the lung against microbial…
- Derrick Rossi, Ph.D.
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The unique ability of stem cells to perpetuate themselves through self-renewal, and to give rise to mature effector cell types in a…
- Leslie Silberstein, M.D.
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Silberstein Lab
A long-term objective of Dr. Silberstein’s research laboratory is to better define niche-induced signals and their intracellular pathways controlling…
- Timothy Springer, Ph.D.
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Adhesion molecules on lymphocytes and leukocytes regulate cell interactions in development, antigen recognition, homing, and inflammation. The Springer lab focuses on integrins,…
- Denisa D. Wagner, Ph.D.
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The Wagner lab studies how blood cells respond rapidly to injury or stressful situations and initiate defensive or reparatory processes. Specifically, they…
- Florian Winau, M.D.
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The Winau lab studies diverse aspects of antigen presentation, a process pivotal for activation of T-lymphocytes. Winau and colleagues investigate three principal…
- Wesley Wong, Ph.D.
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We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a focus on the role…
- Hao Wu, Ph.D.
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The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors.…
- Yi Zhang, Ph.D.
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Epigenetic modifications, particularly DNA methylation and covalent histone modifications, play an important role in regulating chromatin dynamics and therefore have a significant…
