Areas of Research
Principal Investigators in this Research Area:
Neutrophils and Pulmonary Infection
The Remold-O’Donnell Laboratory studies the role of SerpinB1 in protecting the host defenses of… More
A long-term objective of Dr. Silberstein’s research laboratory is to better define niche-induced signals and… More
Adhesion molecules on lymphocytes and leukocytes regulate cell interactions in development, antigen recognition, homing, and inflammation. The Springer… More
The Wagner lab studies how blood cells respond rapidly to injury or stressful situations and initiate defensive or… More
We are interested in understanding the physical basis of how biological systems work at the nanoscale, with a… More
Adhesion molecules are sticky cell surface molecules that facilitate intercellular binding and communication. They govern cell-to-cell interactions and are necessary for embryonic development, cell growth and differentiation, pathogen detection, inflammation, and wound repairs.
We are a world leader in adhesion molecule research, providing an explosion of information from the sub-molecular level to that of the whole organism. Researchers are specifically investigating molecules and their receptors that are involved in two survival mechanisms: the homing of immune cells to inflamed or infected tissues; and the recruitment of blood-clotting platelets to the site of a vascular wound.
Understanding the function of adhesion molecules will lead to ways of preventing inflammatory disease. Obstructing the movement of inflammatory and immune cells, for example, can help treat psoriasis. The FDA recently approved molecules discovered in the Springer Lab for clinical use against this affliction.
Our research in this area benefits from major advances in transgenic and knockout mouse technology. Powerful imaging tools, including intravital fluorescence microscopy and X-ray crystallography, also assist our scientists in scoring discoveries about adhesion molecules.
Investigators are pursuing these challenges in the area of adhesion molecules:
- Understanding how adhesion molecules work at the molecular level;
- Predicting the structure of molecules;
- Understanding the biophysics of how adhesion molecules enter and exit from the bloodstream;
- Searching for small molecules in a drug discovery program that might impede the function of adhesion molecules and lead to ways of preventing inflammatory disease, including atherosclerosis and thrombosis.
Related News and Announcements
Kimberly Martinod, a graduate student in Denisa Wagner’s laboratory, received the Junior Investigator Award for Women. She presented her poster titled “Peptidylarginine deiminase 4-dependent generation of neutrophil extracellular traps is crucial for deep vein thrombosis… Read Full Article »
Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils'… Read Full Article »
The scenes are familiar from biology textbooks. A long string of DNA is copied to form a matching strand. A… Read Full Article »