A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital.
When the drug Velcade® came on the market in 2003, it was seen as a godsend for patients with multiple myeloma, an intractable blood cancer that until then was uniformly fatal.
A team led by Dr. Qian Yin, a senior postdoctoral fellow in Dr. Hao Wu’s lab used structural and functional approaches to elucidate how an intricate interplay between p202, a critical checkpoint protein involved in autoimmunity, and a protein that monitors the cytoplasm for abnormal dsDNA (AIM2) may be involved in lupus pathogenesis.
Gut bacteria exert a dramatic, systemic effect on the development of the immune system's B-lymphocytes, according to a new mouse study by researchers at Boston Children's Hospital.
Researchers at the Program in Cellular and Molecular Medicine at Boston Children's Hospital (BCH), previously known as the Immune Disease Institute (PCMM/IDI), have explained important mechanisms underlying immune memory, specifically how antigens are retained over long periods of time and made repeatedly accessible to B cells.
According to members of the Zhang lab, stem cells that strongly express a gene called WNT3 are biased to develop into cells and tissues including pancreas, liver and bladder.
Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils' role in dangerous blood clots
A team led by Timothy A. Springer, Ph.D., of Boston Children's Program in Cellular and Molecular Medicine, used X-ray crystallography to work out both the three-dimensional structure of TRAP and how it changes shape as it helps the parasite move about.
Isabel Beerman, Derrick Rossi and colleagues tell us about changes in the epigenome of blood stem cells as they age
Judy Lieberman and Linfeng Huang reported important progress in production of siRNAs.
In a recent paper in Cell, Sun Hur, Ph.D., and her group spotlight one of our dsRNA pattern recognizers, a protein called MDA5.
Hao Wu and colleagues asked if one of these molecules could break the back of a treatment-resistant kind of lymphoma?
Goldfeld lab determines that NFAT5 plays a crucial role in direct regulation of HIV-1 replication by MTb, but also demonstrate for the first time a general role for NFAT5 in control of gene expression, mediated by MTb and the TLR signal transduction pathway.
Wong lab researchers use a unique "micropiston" to measure mechanical properties of individual Escherichia Coli chromosomes.
Single-molecule movies capture the chaotic origins of dynamic assembly in cells.
A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital. This discovery could help provide clues to the cause of some kinds of neonatal growth defects and may also help advance the development of stem cell models of disease.
The findings were reported online Dec. 1 in Nature by a research team led by Yi Zhang, PhD, and Shinpei Yamaguchi, PhD, of Boston Children's Program in Cellular and Molecular Medicine.
Each of our cells carries two copies, or alleles, of every gene in our genome, one from each parent. In certain genes, one allele is imprinted—marked with small chemical tags called methyl groups—to keep it silent and prevent biological conflicts from arising between the two copies.
Before they mature into sperm or egg cells, primordial germ cells' imprinting patterns are erased and then… Read More »
Dr. Timothy Springer is among the 388 newly-elected AAAS Fellows who were recognized by their peers for their efforts to advance science or its applications. The new AAAS Fellows, whose names will be… Read More »
Dr. Bjoern Schwer, Instructor in Pediatrics, has received the 2013 Martin D. Abeloff, MD V Scholar Award from The V Foundation for Cancer Research. The Abeloff Award… Read More »