Published this week in Nature Immunology, the Winau lab in collaboration with Stuart Orkin’s group revealed how the histone demethylase UTX regulates the development of natural killer T cells through multiple epigenetic mechanisms.
Reporting this week in JEM, the Winau lab identified a new pathway involving scramblase TMEM16F that preserves efficient T cell responses to control viral infection. These findings provide a novel target for therapy against chronic diseases, such as cancer, HIV and hep B virus infections.
A group led by Frederick Alt, developed a technology to greatly speed up HIV development in mice. The group’s method generates mouse models with built-in human immune systems. The model rapidly recapitulates what the human immune system does, enabling researchers to continuously test and tweak potential HIV vaccines.
The Winau Lab has discovered a new mechanism for skin inflammation. This work, recently published in Nature Immunology, forms the basis for future therapeutic strategies against inflammatory skin diseases, such as poison ivy dermatitis and psoriasis.
Reporting this week in Nature, scientists in Boston Children’s Hospital’s Program in Cellular and Molecular Medicine (PCMM) describe new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.
Now, a research team led by Wesley Wong has made a major advance by developing an inexpensive method that permits analysis of the force responses of thousands of similar molecules simultaneously.
Study reveals new avenue for thinking about brain development, brain tumors and neurodevelopmental/psychiatric diseases
Over the last couple of years Judy Lieberman’s lab has uncovered evidence for what could be an evolutionarily ancient form of immune defense directed against intracellular pathogens. In a 2014 Cell paper, her lab revealed that the immune system’s T-cells can kill intracellular bacteria directly by pummeling infected cells with three proteins: perforin, granulysin and granzymes
In a recent Cell paper, a team led by Hao Wu, PhD, used electronic microscopy to reveal how RAG1 and 2 interact at a structural level, both with each other and with DNA.
Researchers in Dr. Fred Alt's laboratory used a novel in vivo mouse model system to resolve longstanding questions regarding the influence of DNA sequences on AID targeting and mutational outcomes during antibody diversification.
In a new paper in Cell Stem Cell, Dr. Yi Zhang's team report that they’ve extended their work to improve the efficiency of SCNT in human cells.
The Program in Cellular and Molecular Medicine (PCMM) would like to welcome Dr. Hidde Ploegh who has joined the Department of Medicine at Boston Children's Hospital as of December 2016. Pending completion of his appointment to Harvard Medical School, Dr. Ploegh, who is a former PCMM Scientific Advisory Board member, has been nominated to become a PCMM Investigator and also has been nominated to serve as the first incumbent of a Professorship newly endowed by G.D. Yancopoulos in honor of Frederick W. Alt at Boston Children’s Hospital and Harvard Medical School. Prior to joining PCMM, Dr. Ploegh was a Professor of Biology at MIT since 2005. Dr. Ploegh is a world-renowned immunologist, cell biologist, and biochemist, who has won many awards for his research. Most recently, Dr. Ploegh was elected as a member of the United States National Academy of Sciences. His research focuses on molecular immunology, particularly the cell biology… Read More »
Congratulations to Ross Cheloha and Sadeem Ahmad, who have each been awarded a post-doctoral fellowship from the Cancer Research Institute (CRI).
Ross Cheloha (left), a postdoctoral fellow… Read More »
Dr. Li, a postdoctoral fellow in the Springer lab, will test the hypothesis that the conformational ensemble of integrin α5β1 specifies its function, and rational perturbation of its ensemble… Read More »