A DNA-unraveling enzyme in neutrophils is essential for deep vein thrombosis
Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils' role in dangerous blood clots
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Judy Lieberman and Linfeng Huang reported important progress in production of siRNAs.
A picture is worth a thousand words for understating innate immunity
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Forcing lymphoma cells into withdrawal, one subtype at a time
Hao Wu and colleagues asked if one of these molecules could break the back of a treatment-resistant kind of lymphoma?
A new role for NFAT5 in innate immunity and in the regulation of HIV by TB co-infection
Goldfeld lab determines that NFAT5 plays a crucial role in direct regulation of HIV-1 replication by MTb, but also demonstrate for the first time a general role for NFAT5 in control of gene expression, mediated by MTb and the TLR signal transduction pathway.
The bacterial chromosome as a soft spring
Wong lab researchers use a unique "micropiston" to measure mechanical properties of individual Escherichia Coli chromosomes.
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Development of a Method to Reprogram Antibody Producing B Cells to Functional-Grade Induced Pluripotent Stem Cells
Alt lab finds method to dramatically improve the quality of iPSCs.
Featured News Story
A DNA-unraveling enzyme in neutrophils is essential for deep vein thrombosis
Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils' role in dangerous blood clots
It takes more than platelets, thrombin and fibrin to build deep vein thrombosis (DVT). Increasingly, researchers are recognizing that neutrophils-cells better known for their role in immune defense-play an active role in DVT formation by releasing platelet-catching nets made of chromatin, a tightly-wound mix of DNA and associated proteins.
The team of researchers from Boston Children's Hospital's Program in Cellular and Molecular Medicine report that mice lacking a neutrophil enzyme called PAD4, which helps unravel the chromatin in neutrophils' nuclei, cannot form DVTs. Their work, a first step toward developing safer, more targeted treatments for DVTs, was published online [Proc Natl Acad Sci 2013 May 6].
DVTs are… Read More »
Announcements
Junior Investigator Award for Women at the ATVB Scientific…
Kimberly Martinod, a graduate student in Denisa Wagner’s laboratory, received the Junior Investigator Award for Women. She presented her poster titled “Peptidylarginine… Read More »
Big things from small places: Modified RNAs eyed as…
A technology from a small research institute, originally developed as a safer way to make embryonic-like stem cells, just hooked a very large fish. As The New York Times reported March 21, pharma giant… Read More »
