A DNA-unraveling enzyme in neutrophils is essential for deep vein thrombosis

Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils' role in dangerous blood clots

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A new role for NFAT5 in innate immunity and in the regulation of HIV by TB co-infection

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The bacterial chromosome as a soft spring

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Featured News Story

A DNA-unraveling enzyme in neutrophils is essential for deep vein thrombosis

A DNA-unraveling enzyme in neutrophils is essential for deep vein thrombosis

Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils' role in dangerous blood clots

It takes more than platelets, thrombin and fibrin to build deep vein thrombosis (DVT). Increasingly, researchers are recognizing that neutrophils-cells better known for their role in immune defense-play an active role in DVT formation by releasing platelet-catching nets made of chromatin, a tightly-wound mix of DNA and associated proteins.

The team of researchers from Boston Children's Hospital's Program in Cellular and Molecular Medicine report that mice lacking a neutrophil enzyme called PAD4, which helps unravel the chromatin in neutrophils' nuclei, cannot form DVTs. Their work, a first step toward developing safer, more targeted treatments for DVTs, was published online [Proc Natl Acad Sci 2013 May 6].

DVTs are… Read More »

Announcements

Junior Investigator Award for Women at the ATVB Scientific Sessions 2013

Junior Investigator Award for Women at the ATVB Scientific…

Kimberly Martinod, a graduate student in Denisa Wagner’s laboratory, received the Junior Investigator Award for Women.  She presented her poster titled “Peptidylarginine… Read More »

Big things from small places: Modified RNAs eyed as a way to make new drugs

Big things from small places: Modified RNAs eyed as…

A technology from a small research institute, originally developed as a safer way to make embryonic-like stem cells, just hooked a very large fish. As The New York Times reported March 21, pharma giant… Read More »

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