A first for CRISPR: Cutting genes in blood stem cells

In a paper published in Cell Stem Cell, a team led by Derrick Rossi, PhD, report a first for CRISPR: efficiently and precisely editing clinically relevant genes out of cells collected directly from people. Specifically, they applied CRISPR to human hematopoietic stem and progenitor cells (HSPCs) and T-cells.

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Removing roadblocks to therapeutic cloning to produce stem cells

To help find barriers associated with a cloning technique called somatic cell nuclear transfer (SCNT), Drs. Yi Zhang and Shogo Matoba generated mouse embryos through either SCNT or IVF and compared their gene expression profiles at the very early stages of development.

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1 in 20,000: Identifying hematopoietic stem cells in bone marrow

Roi Gazit, Pankaj Mandal and Derrick Rossi have engineered a hematopoietic stem cell specific reporter mouse that permits facile detection of rare blood forming stem cells based on single color fluorescence.

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DNA damage repair is attenuated in quiescent hematopoietic stem cells, contributing to age-dependent DNA damage accumulation

Without active DNA repair, damage beyond strand breaks could accumulate, giving rise to mutations leading to age-related blood disorders.

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Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

Michael Walch, Farokh Dotiwala and Judy Lieberman unveil a new role for killer cells in bacterial defense. In a recent Cell paper they show that granulysin, an antimicrobial protein present in the cytotoxic granules of human killer lymphocytes, delivers death-inducing granzymes into bacteria, where they rapidly kill bacteria and limit the spread of infection.

Scientists turn back the clock on blood cells, reprogram them into blood stem cells

Induced hematopoietic stem cells, or iHSCs, bear characteristic features of natural HSCs, represent milestone in regenerative medicine

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Drawing a ring around antiviral immunity

Ubiquitin doesn't just tag proteins for recycling. It also may help keep our antiviral immune response in balance.

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Study identifies protein that helps developing germ cells wipe genes clean of past imprints

A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital.

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How do you stop an aggressive breast cancer? Keep it from recycling

When the drug Velcade® came on the market in 2003, it was seen as a godsend for patients with multiple myeloma, an intractable blood cancer that until then was uniformly fatal.

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Unraveling the link between DNA sensing and lupus

A team led by Dr. Qian Yin, a senior postdoctoral fellow in Dr. Hao Wu’s lab used structural and functional approaches to elucidate how an intricate interplay between p202, a critical checkpoint protein involved in autoimmunity, and a protein that monitors the cytoplasm for abnormal dsDNA (AIM2) may be involved in lupus pathogenesis.

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Study finds that microbes influence B-cell development in the gut.

Gut bacteria exert a dramatic, systemic effect on the development of the immune system's B-lymphocytes, according to a new mouse study by researchers at Boston Children's Hospital.

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Follicular dendritic cells: Libraries of immune memory

Researchers at the Program in Cellular and Molecular Medicine at Boston Children's Hospital (BCH), previously known as the Immune Disease Institute (PCMM/IDI), have explained important mechanisms underlying immune memory, specifically how antigens are retained over long periods of time and made repeatedly accessible to B cells.

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Featured News Story

Removing roadblocks to therapeutic cloning to produce stem cells

Removing roadblocks to therapeutic cloning to produce stem cells

We all remember Dolly the sheep, the first mammal to be born through a cloning technique called somatic cell nuclear transfer (SCNT). As with the thousands of other SCNT-cloned animals ranging from mice to mules, researchers created Dolly by using the nucleus from a grown animal’s cell to replace the nucleus of an egg cell from the same species.

The idea behind SCNT is that the egg’s cellular environment kicks the transferred nucleus’s genome into an embryonic state, giving rise to an animal genetically identical to the nucleus donor. SCNT is also a technique for generating embryonic stem cells for research purposes.

While researchers have accomplished SCNT in many animal species, it could work better than it does now. It took the scientists who cloned Dolly 277 tries before they got it right. To this day, SCNT efficiency—that is, the percent of nuclear… Read More »

Announcements

Dr. Wesley Wong receives Beckman Young Investigator Award

Dr. Wesley Wong receives Beckman Young Investigator…

The Arnold and Mabel Beckman Foundation has honored Dr. Wesley Wong with a Beckman Young Investigator Award, which recognizes promising young faculty in chemistry… Read More »

Congratulations to Fred Alt, Recipient of the 44th Rosenstiel Award for Distinguished Work in Biomedical Science

Congratulations to Fred Alt, Recipient of the 44th…

The 44th Rosenstiel Award for Distinguished Work in Biomedical… Read More »

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