DNA damage repair is attenuated in quiescent hematopoietic stem cells, contributing to age-dependent DNA damage accumulation

Without active DNA repair, damage beyond strand breaks could accumulate, giving rise to mutations leading to age-related blood disorders.

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Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

Michael Walch, Farokh Dotiwala and Judy Lieberman unveil a new role for killer cells in bacterial defense. In a recent Cell paper they show that granulysin, an antimicrobial protein present in the cytotoxic granules of human killer lymphocytes, delivers death-inducing granzymes into bacteria, where they rapidly kill bacteria and limit the spread of infection.

1 in 20,000: Identifying hematopoietic stem cells in bone marrow

Roi Gazit, Pankaj Mandal and Derrick Rossi have engineered a hematopoietic stem cell specific reporter mouse that permits facile detection of rare blood forming stem cells based on single color fluorescence.

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Scientists turn back the clock on blood cells, reprogram them into blood stem cells

Induced hematopoietic stem cells, or iHSCs, bear characteristic features of natural HSCs, represent milestone in regenerative medicine

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Drawing a ring around antiviral immunity

Ubiquitin doesn't just tag proteins for recycling. It also may help keep our antiviral immune response in balance.

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Study identifies protein that helps developing germ cells wipe genes clean of past imprints

A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital.

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How do you stop an aggressive breast cancer? Keep it from recycling

When the drug Velcade® came on the market in 2003, it was seen as a godsend for patients with multiple myeloma, an intractable blood cancer that until then was uniformly fatal.

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Unraveling the link between DNA sensing and lupus

A team led by Dr. Qian Yin, a senior postdoctoral fellow in Dr. Hao Wu’s lab used structural and functional approaches to elucidate how an intricate interplay between p202, a critical checkpoint protein involved in autoimmunity, and a protein that monitors the cytoplasm for abnormal dsDNA (AIM2) may be involved in lupus pathogenesis.

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Study finds that microbes influence B-cell development in the gut.

Gut bacteria exert a dramatic, systemic effect on the development of the immune system's B-lymphocytes, according to a new mouse study by researchers at Boston Children's Hospital.

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Follicular dendritic cells: Libraries of immune memory

Researchers at the Program in Cellular and Molecular Medicine at Boston Children's Hospital (BCH), previously known as the Immune Disease Institute (PCMM/IDI), have explained important mechanisms underlying immune memory, specifically how antigens are retained over long periods of time and made repeatedly accessible to B cells.

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Biomarker could help scientists choose the right cell line when conducting stem cell experiments

According to members of the Zhang lab, stem cells that strongly express a gene called WNT3 are biased to develop into cells and tissues including pancreas, liver and bladder.

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A DNA-unraveling enzyme in neutrophils is essential for deep vein thrombosis

Research led by graduate student Kimberly Martinod and Denisa Wagner, Ph.D., adds a new twist to the growing body of evidence of neutrophils' role in dangerous blood clots

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Moving in on what makes malaria move

A team led by Timothy A. Springer, Ph.D., of Boston Children's Program in Cellular and Molecular Medicine, used X-ray crystallography to work out both the three-dimensional structure of TRAP and how it changes shape as it helps the parasite move about.

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Featured News Story

The costs of quiescence, for cars and blood cells

The costs of quiescence, for cars and blood cells

BOSTON (July 7, 2014) -- My first car was my grandfather’s 1980 Chevrolet Malibu. For about two years before my family gave it to me, it sat unused in Grandpa’s garage—just enough time for all of the belts and hoses to rot and the battery to trickle down to nothing.

Why am I telling this story? Because it’s much like what happens to the DNA in our blood-forming stem cells as we age.

Hematopoietic stem cells (HSCs) spend very little of their lives in an active, cycling state. Much of the time they’re quiescent or dormant, keeping their molecular and metabolic processes dialed down. These quiet periods allow the cells to conserve resources, but also give time an opportunity to wear away at their genes.

“DNA damage doesn’t just arise from mistakes during replication,” explains Derrick Rossi, PhD, a stem cell biology researcher with Boston Children’s Hospital’s Program in Cellular and Molecular Medicine. “There… Read More »


Congratulations to Fred Alt, Recipient of the 44th Rosenstiel Award for Distinguished Work in Biomedical Science

Congratulations to Fred Alt, Recipient of the 44th…

The 44th Rosenstiel Award for Distinguished Work in Biomedical… Read More »

Dr. Hao Wu Received  the Pathway to Independence Award (K99/R00) from NIH

Dr. Hao Wu Received the Pathway to Independence Award…

Dr. Hao Wu, a postdoctoral fellow in Zhang lab, was recently awarded the Pathway to Independence Award by the National Institutes of Health's National Human Genome Research… Read More »

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