UTX makes NKT

Published this week in Nature Immunology, the Winau lab in collaboration with Stuart Orkin’s group revealed how the histone demethylase UTX regulates the development of natural killer T cells through multiple epigenetic mechanisms.

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Modulation of Scramblase: a novel paradigm to fight chronic infection and cancer

Reporting this week in JEM, the Winau lab identified a new pathway involving scramblase TMEM16F that preserves efficient T cell responses to control viral infection. These findings provide a novel target for therapy against chronic diseases, such as cancer, HIV and hep B virus infections.

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Keeping up with HIV mutations: Building a nimble vaccine test system

A group led by Frederick Alt, developed a technology to greatly speed up HIV development in mice. The group’s method generates mouse models with built-in human immune systems. The model rapidly recapitulates what the human immune system does, enabling researchers to continuously test and tweak potential HIV vaccines.

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CD1a molecule as a potential therapeutic target in inflammatory skin diseases

The Winau Lab has discovered a new mechanism for skin inflammation. This work, recently published in Nature Immunology, forms the basis for future therapeutic strategies against inflammatory skin diseases, such as poison ivy dermatitis and psoriasis.

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When antibiotics fail: A potential new angle on severe bacterial infection and sepsis

Reporting this week in Nature, scientists in Boston Children’s Hospital’s Program in Cellular and Molecular Medicine (PCMM) describe new potential avenues for controlling both sepsis and the runaway bacterial infections that provoke it.

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Democratizing high-throughput single molecule force analysis

Now, a research team led by Wesley Wong has made a major advance by developing an inexpensive method that permits analysis of the force responses of thousands of similar molecules simultaneously.

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DNA breaks in nerve cells' ancestors cluster in specific genes

Study reveals new avenue for thinking about brain development, brain tumors and neurodevelopmental/psychiatric diseases

Microptosis: Programmed death for microbes?

Over the last couple of years Judy Lieberman’s lab has uncovered evidence for what could be an evolutionarily ancient form of immune defense directed against intracellular pathogens. In a 2014 Cell paper, her lab revealed that the immune system’s T-cells can kill intracellular bacteria directly by pummeling infected cells with three proteins: perforin, granulysin and granzymes

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Putting structure around the genetic basis of some immune diseases

In a recent Cell paper, a team led by Hao Wu, PhD, used electronic microscopy to reveal how RAG1 and 2 interact at a structural level, both with each other and with DNA.

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Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes

Researchers in Dr. Fred Alt's laboratory used a novel in vivo mouse model system to resolve longstanding questions regarding the influence of DNA sequences on AID targeting and mutational outcomes during antibody diversification.

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Improved cell cloning technique makes the jump from mice to humans

In a new paper in Cell Stem Cell, Dr. Yi Zhang's team report that they’ve extended their work to improve the efficiency of SCNT in human cells.

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Featured News Story

Hidde Ploegh Joins PCMM

Hidde Ploegh Joins PCMM

The Program in Cellular and Molecular Medicine (PCMM) would like to welcome Dr. Hidde Ploegh who has joined the Department of Medicine at Boston Children's Hospital as of December 2016.   Pending completion of his appointment to Harvard Medical School, Dr. Ploegh, who is a former PCMM Scientific Advisory Board member, has been nominated to become a PCMM Investigator and also has been nominated to serve as the first incumbent of a Professorship newly endowed by G.D. Yancopoulos in honor of Frederick W. Alt at Boston Children’s Hospital and Harvard Medical School.  Prior to joining PCMM, Dr. Ploegh was a Professor of Biology at MIT since 2005. Dr. Ploegh is a world-renowned immunologist, cell biologist, and biochemist, who has won many awards for his research. Most recently, Dr. Ploegh was elected as a member of the United States National Academy of Sciences.  His research focuses on molecular immunology, particularly the cell biology… Read More »

Announcements

Ross Cheloha and Sadeem Ahmad were awarded CRI Post-doctoral Fellowships

Ross Cheloha and Sadeem Ahmad were awarded CRI Post-doctoral…

Congratulations to Ross Cheloha and Sadeem Ahmad, who have each been awarded a post-doctoral fellowship from the Cancer Research Institute (CRI).

Ross Cheloha (left), a postdoctoral fellow… Read More »

Dr. Jing Li was awarded Susan G. Komen Breast Cancer Foundation Fellowship

Dr. Jing Li was awarded Susan G. Komen Breast Cancer…

Dr. Li, a postdoctoral fellow in the Springer lab, will test the hypothesis that the conformational ensemble of integrin α5β1 specifies its function, and rational perturbation of its ensemble… Read More »

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