Harvard researchers genetically ‘edit’ human blood stem cells
To help find barriers associated with a cloning technique called somatic cell nuclear transfer (SCNT), Drs. Yi Zhang and Shogo Matoba generated mouse embryos through either SCNT or IVF and compared their gene expression profiles at the very early stages of development.
Roi Gazit, Pankaj Mandal and Derrick Rossi have engineered a hematopoietic stem cell specific reporter mouse that permits facile detection of rare blood forming stem cells based on single color fluorescence.
Without active DNA repair, damage beyond strand breaks could accumulate, giving rise to mutations leading to age-related blood disorders.
Michael Walch, Farokh Dotiwala and Judy Lieberman unveil a new role for killer cells in bacterial defense. In a recent Cell paper they show that granulysin, an antimicrobial protein present in the cytotoxic granules of human killer lymphocytes, delivers death-inducing granzymes into bacteria, where they rapidly kill bacteria and limit the spread of infection.
Induced hematopoietic stem cells, or iHSCs, bear characteristic features of natural HSCs, represent milestone in regenerative medicine
Ubiquitin doesn't just tag proteins for recycling. It also may help keep our antiviral immune response in balance.
A protein called Tet1 is partly responsible for giving primordial germ cells a clean epigenetic slate before developing into sperm and egg cells, according to a new study by researchers at Boston Children's Hospital.
When the drug Velcade® came on the market in 2003, it was seen as a godsend for patients with multiple myeloma, an intractable blood cancer that until then was uniformly fatal.
A team led by Dr. Qian Yin, a senior postdoctoral fellow in Dr. Hao Wu’s lab used structural and functional approaches to elucidate how an intricate interplay between p202, a critical checkpoint protein involved in autoimmunity, and a protein that monitors the cytoplasm for abnormal dsDNA (AIM2) may be involved in lupus pathogenesis.
Gut bacteria exert a dramatic, systemic effect on the development of the immune system's B-lymphocytes, according to a new mouse study by researchers at Boston Children's Hospital.
Researchers at the Program in Cellular and Molecular Medicine at Boston Children's Hospital (BCH), previously known as the Immune Disease Institute (PCMM/IDI), have explained important mechanisms underlying immune memory, specifically how antigens are retained over long periods of time and made repeatedly accessible to B cells.
Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General(MGH) and Boston Children’s hospitals (BCH) for the first time have used a relatively new gene-editing technique to create what could prove to be an effective technique for blocking HIV from invading and destroying patients’ immune systems.
This is the first published report of a group using CRISPR Cas technology ― it stands for clustered regularly interspaced short palindromic repeat-activated cells ― to efficiently and precisely edit clinically relevant genes out of cells collected directly from people, in this case human blood-forming stem cells… Read More »
The Arnold and Mabel Beckman Foundation has honored Dr. Wesley Wong with a Beckman Young Investigator Award, which recognizes promising young faculty in chemistry… Read More »
The 44th Rosenstiel Award for Distinguished Work in Biomedical… Read More »